hTRPC5/HEK293
CBP75046
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| I. Background | |||
| TRPC5（Transient Receptor Potential Canonical 5）是 TRP 通道家族中经典型亚家族的 一员，本质上是一种钙离子通透性的非选择性阳离子通道。它的核心工作原理围绕其作为 细胞信号转导“效应器”的角色展开：TRPC5 定位于细胞膜上，顺利获得允许钠离子和钙离子 等阳离子跨膜流动，将细胞外的化学信号（如激素、神经递质）转化为细胞内的电信号和 钙信号变化，从而调控神经元兴奋性、代谢平衡和肾脏滤过等多种生理过程。其功能异常与肥胖、疼痛感知异常、情绪障碍及进行性肾病密切相关，因此成为当前药物研发的热门 靶点。 | |||
| II. Background | |||
| TRPC5 HEK293，在 HEK293 细胞上，稳定表达人 TRPC5。 | |||
| III. Introduction | |||
| Host Cell: | HEK293 | ||
| Expressed gene: | TRPC5 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | DMEM + 10% FBS + 2μg/ml Puromycin | ||
| Storage: | Liquid nitrogen | ||
| IV. Description of Host Cell Line | |||
| Organism: | Homo sapiens, human | ||
| Tissue: | Embryonic kidney | ||
| Disease: | Normal | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| V. Representative Data | |||
Figure 1. Potentiation by AM237 in TRPC5 HEK293(C49).
Figure 2. Inhibition by AC1903 in TRPC5 HEK293(C49).
