Cyno IL36 Effector Reporter Cell
CBP74696
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| I. Background | |
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食蟹猴（Cyno）的IL-36系统与人类高度同源，主要包括三种激动剂配体（IL-36α、IL-36β、IL-36γ） 和一个功能性受体复合物（IL-36R/IL-1RAcP）。该系统是IL-1细胞因子家族的重要成员，在皮肤、肺、胃肠道等上皮组织中发挥关键的促炎信号作用，其过度激活与银屑病等炎症性疾病密切相关。 |
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| II. Description | |
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Cyno IL36 Effector Reporter Cell 报告基因药靶模型很好的模拟了 IL36 的信号转导过程。 |
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| III. Introduction | |
| Expressed gene: | Cyno IL36R |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | MEM + 10% FBS + 1% NEAA+ 1mM NaP+1 μg/ml Puromycin+ 100 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
IV. Representative Data Figure 1. Recombinant Cyno IL36 Effector Reporter Cell constitutively expressing Cyno IL36.  Figure 2. Dose Response of Human IL36α in Cyno IL36 Effector Reporter Cell(C5).  Figure 3. Inhibition of Human Recombinant IL36α Induced Reporter Activity by IL1RAP Blocking Abs in Cyno IL36 Effector Reporter Cell ( C5).  Figure 4. Inhibition of Human Recombinant IL36α Induced Reporter Activity by IL36R Blocking Ab in Cyno IL36 Effector Reporter Cell(C5). |
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